Excessive or extended doses of any of those behaviors or substances aren’t sustainable or wholesome (spend an excessive amount of time in chilly water, and also you’re gonna get hypothermia). However briefly bursts, the little little bit of irritation that these stressors trigger is simply sufficient to knock you out of comfy homeostasis and activate quite a lot of mobile mechanisms and signaling pathways that promote stress resilience, restore mobile injury (by way of processes like autophagy), restore DNA, fight oxidative stress, produce new mitochondria, cut back irritation, assist elimination of poisons, enhance blood sugar regulation, cut back threat of most cancers, and extra, explains Rountree.