Preoperative carriage of Staphylococcus aureus, particularly within the nostril, is related to elevated danger of S aureus surgical-site and postoperative bloodstream infections (SA SSI/BSI), researchers reported yesterday in Open Discussion board Infectious Ailments.
Greater bacterial load within the nostril and S aureus colonization at different physique websites additional elevated the chance, researchers with the ASPIRE-SSI examine group discovered. ASPIRE-SSI was a potential observational cohort examine that adopted grownup surgical sufferers at 33 European hospitals for as much as 90 days after surgical procedure to evaluate the incidence of and danger elements for postoperative S aureus infections.
S aureus is thought to colonize 20% to 30% of the human inhabitants at totally different physique websites, significantly the nostril but additionally the throat, axilla, and perineal area, and former research have proven that it causes roughly 30% of SSIs. This examine aimed to find out the results of S aureus nasal carriage alone, carriage at a number of websites, and bacterial load on the chance of growing SA SSI/BSI.
Findings assist decolonization methods
Of the 5,004 sufferers included within the examine cohort, 3,369 (67.3%) have been S aureus carriers. Of the 100 SA SSI/BSIs that occurred, 86 occurred in S aureus carriers. Each S aureus nasal carriage (adjusted hazard ratio [aHR], 4.2; 95% confidence interval [CI], 2.0 to eight.6) and S aureus carriage at any physique web site (aHR, 4.6; 95% CI, 2.1 to 10.0) have been independently related to an elevated danger of growing SA SSI/BSI inside 90 days of surgical procedure.
The chance elevated because the variety of preoperatively colonized bodily websites elevated (aHR, 3.5 to eight.5) because the variety of colonized websites elevated from one to 3) and because the S aureus bacterial load within the nostril elevated (aHR, 1.8 to three.4). However extranasal carriage solely was not independently related to elevated SA SSI/BSI danger.
The examine authors say the findings are consistent with earlier research and supply additional proof in assist of S aureus decolonization methods.
“Such interventions have been proven to be efficacious, efficient, and cost-effective,” they wrote.
