Pembrolizumab plus chemotherapy improves disease-free survival (DFS) in sufferers with high-risk endometrial most cancers after surgical procedure with healing intent, in accordance with a research revealed on-line Oct. 16 within the Journal of Scientific Oncology.
Brian M. Slomovitz, M.D., from Mount Sinai Medical Heart in Miami Seashore, and colleagues performed a protocol-prespecified subgroup evaluation of sufferers with mismatch repair-deficient (dMMR) endometrial most cancers from the section 3 ENGOT-en11/GOG-3053/KEYNOTE-B21 research present process surgical procedure with healing intent. The evaluation included sufferers randomly assigned to pembrolizumab 200 mg or placebo (six cycles) plus carboplatin-paclitaxel (4 to 6 cycles) each three weeks, then pembrolizumab 400 mg (141 sufferers) or placebo (140 sufferers) each six weeks (six cycles).
The researchers reported that an interim evaluation confirmed DFS favored pembrolizumab (hazard ratio, 0.31), with median DFS not reached in both group. For pembrolizumab and placebo, two-year DFS charges had been 92.4 and 80.2 p.c, respectively. No new security alerts had been reported.
“Preplanned subgroup evaluation primarily based on the research’s stratification elements means that pembrolizumab plus chemotherapy improves DFS and is clinically related for sufferers with dMMR tumors within the curative-intent setting,” the authors write.
A number of authors disclosed ties to pharmaceutical corporations, together with Merck, which manufactures pembrolizumab and funded the research.
Extra info:
Brian M. Slomovitz et al, Pembrolizumab or Placebo Plus Adjuvant Chemotherapy With or With out Radiotherapy For Newly Recognized, Excessive-Threat Endometrial Most cancers: Ends in Mismatch Restore-Poor Tumors, Journal of Scientific Oncology (2024). DOI: 10.1200/JCO-24-01887
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