Joey Savage Launches Savage Nutra Consulting

0:00 – Disclaimer – Joey is No Longer with Glaxon / Zero Day Diet

For the reason that filming of this interview with Joey Savage on the 2024 Arnold Traditional on March 2nd, it had come to mild that Glaxon CEO Michael Bischoff had been indicted and prosecuted for promoting medication mislabeled as dietary supplements within the 2016-2018 time span by means of his firm, G.D. Diet LLC.[1]

After filming this, Joey introduced his resignation from Glaxon (run underneath the entity Day One Distribution LLC) and Zero Day Diet LLC (Bischoff’s contract manufacturing entity that was renamed from G.D. Diet).[2]

This podcast was filmed earlier than that revelation, and all through this dialog, Joey nonetheless refers to his employment with Glaxon, which is not the case as that is revealed. Regardless of these modifications, that is nonetheless an exceptional dialog, and we needed to publish it in its entirety.

It’s vital to keep in mind that the actions Bischoff has been indicted for befell between 2016 and 2018, properly earlier than Joey joined Glaxon. So please don’t take this indictment as a mirrored image on Joey’s character, or PricePlow’s collaboration with him.

We expect Joey’s new consulting agency, Savage Nutra, is a superb scoop, and we’re stoked to see what Joey does with it.

5:00 – Sponsored by Path Ahead Formulator

This podcast is sponsored by Path Ahead Formulator™.

Path Ahead Formulator is revolutionizing the product improvement and formulation course of for capsules, powders, tablets, and gummy dietary supplements!

This episode is sponsored by Path Ahead Formulator

Their web-based and cellular app streamlines your formulation journey with unparalleled velocity and effectivity. Effortlessly create, modify, and optimize formulations on-the-fly with value breakdowns, packaging configurations, efficiency and overage calculations, and export properly-formatted diet or complement information panels, multi functional intuitive interface.

Say goodbye to these cumbersome formulation spreadsheets you’ve been utilizing and hiya to seamless improvement. Embrace innovation with Path Ahead Formulator — your all-in-one formulation resolution.

Test it out at PathForwardFormulator.com.

5:45 – Interview With Joey Savage Begins (Savage Nutra Scoop)

The cat is out of the bag that Joey Savage, CSO of Glaxon, is launching a solo consulting enterprise referred to as Savage Nutra.

7:00 – What About Glaxon?

A lot has modified since this podcast, when Joey Savage introduced Power Drinks and Cereal to the PricePlow Podcast of their second episode with us (Episode #090)

Regardless of launching Savage Nutra, Joey is (or was, on the time of this interview) nonetheless the Chief Science Officer for Glaxon. The truth that Glaxon had all their 2024 merchandise deliberate upfront left Joey with sufficient bandwidth to run Savage Nutra on the facet.

7:45 – What Is Savage Nutra All About? Any Collabs

Is Savage Nutra a complement firm? Not precisely – though Joey is open to doing licensed collaborations, the enterprise mannequin is targeted extra on hourly consulting jobs like system critiques and complement information label compliance. The goal market is usually business newcomers who don’t know all of the regulatory ins and outs but.

So what sort of mission deserves an official Savage Nutra collab label? If it occurs, the Savage Nutra licensed collab label shall be reserved for long run and revolutionary tasks. An instance of one thing deserving the label could be a six month lengthy mission that nearly creates a brand new product class. One cellphone name isn’t gonna reduce it.

12:00 – Joey’s 5-12 months Plan: Past Sports activities Diet and Best Tasks?

The place does Joey envision himself in 5 years? Does he anticipate shifting his precedence again to work with Glaxon? Joey doesn’t wish to simply seek the advice of with complement manufacturers – he’d additionally love to do hardcore scientific consulting with ingredient suppliers. An instance could be serving to an ingredient firm with notably fascinating stuff broaden their attraction with a brand new pricing technique and advertising technique. Joey’s aim is to finally with with ingredient producers in the US.

Are Joey’s pursuits restricted to only sports activities diet? Completely not – he’s simply as within the normal well being and wellness facet of issues, one instance being his ardour (shared by PricePlow) for NMN. Joey’s all about modulating the methods of the human physique, which is certainly not restricted to only muscle cells and fats cells.

So in that broader class of pursuits, what does Joey discover most fascinating? Proper now he’s a few probiotic tasks which might be outdoors the intestine well being class (e.g., the microbiome has a big effect on neurotransmitter manufacturing).

14:00 – Joey’s Best Microbiome: The Human Trash Compactor

Joey talks about how microbiome range is essential for total immune well being. He desires black belt flora in his intestine that may deal with completely something he throws at them, together with the crappiest meals you possibly can consider – in different phrases, a trash compactor, able to dealing with even microplastics. He additionally makes the purpose that microflora range can enhance immune perform, setting you as much as thrive in the course of the subsequent plandemic.

This pursuits the fellows, they usually notice that no person on the present desires to see Joey’s abilities wasted on pre-workouts. Experience like Joey’s is just too helpful to waste time on growing cookie-cutter merchandise – PricePlow hopes he’ll prove some patentable novel substances.

15:45 – Extra On the Microbiome

Our technique is two-fold: 1. Take away the insults (typically ultra-processed meals with inflammatory seed oils and fat-soluble alcohols), and a pair of. Feed your intestine the weapons it must hold you wholesome

Joey factors out that people aren’t the one organism with a microbiome, and talks about the potential for microbiome switch from different animals. For instance, vultures have the “trash compactor” microbiome Joey was speaking about – they must since they feed on carcasses, and act because the cleanup crew of your complete meals chain. Correspondingly, vulture immunity is totally off the charts, and maybe we may replicate that in people by culturing vulture microflora as a complement.

16:50 – Vulture Story Background and Vulture Energy

Joey describes the circumstances surrounding the genesis of the vulture-derived probiotic concept. It began when somebody got here to him and described how black vulture blood is the normal therapy for most cancers in Colombia, a apply that’s most certainly rooted in vultures’ immunological supremacy. Mike doesn’t need vulture energy, although.

Joey speculates a couple of future the place we don’t want any inoculations earlier than touring, since our vulture-charged immune methods will shred any regional illness that will get thrown at us. Joey’s not nervous about anybody stealing this concept, as a result of not many individuals are keen to gather vulture fecal samples off the highest of cellphone towers. Critically although, he’s not at present engaged on the vulture microbiome, however it’s an amazing instance of the form of factor that pursuits him.

19:00 – Joey’s Ardour: Numerous micro organism!

Jokes apart, what’s Joey most all in favour of engaged on? Given his background in genetics and biochemistry, he thinks so much about genetically modifying micro organism. It’s a uniquely helpful modality since you possibly can prepare a bacterium to do something. Plus, bacterial fermentation is an effective way to create a number of income streams (e.g., utilizing micro organism for carbon seize, after which promoting the top product plus the biomass substrate).

How about micro organism for blood stress? Joey talks about the potential for growing an angiotensin-converting enzyme (ACE) inhibitor probiotic pressure. The facility of this method is that it allows you to repeatedly get the specified impact. That’s as a result of microbiome alterations are like software program set up to your physique, versus capsules that should be taken at common intervals. Due to this, Joey sees an business paradigm shift in the direction of probiotic dietary supplements.

21:45 – Significance of Defending Mental Property

Mike recounts how he’s seen sensible scientists’ concepts get stolen as a result of they shared them with out locking down the mental property, and expresses his concern that the identical may occur to Joey. Thankfully maybe, Joey is doing a whole lot of work with supplies which might be already patented by others, so he’s not too nervous. On the subject of the microplastics factor, he says good luck to anybody who thinks they’ll beat him there.

23:00 – Hordenine’s Legality

The gang focus on hordenine’s authorized standing, and the potential for Joey submitting an NDI for the alkaloid. The consensus is that hordenine has been round for a very long time, and even the FDA says it’s time for hordenine to get an NDI. Hordenine happens naturally in frequent meals, like bitter orange and hops, so it’s unclear why it even wants an NDI within the first place.

24:45 – Giving Again to the Business

Regardless of the fabulous success of many complement firm executives, the luxurious automobiles and the mansions, only a few of them ever assist enhance the business’s credibility by funding medical trials to show the efficacy of dietary dietary supplements. Sadly, it appears to be the case that not a lot of them actually care in regards to the business within the first place – contributing science and serving to enhance folks’s lives is simply not what motivates them.

25:50 – Business Ignorance

Even a whole lot of business insiders, and complement firm bigshots, don’t actually have a clue in regards to the science behind their merchandise. It’s much like how somebody can personal and drive a Ferrari with out understanding something about how the automobile is designed, or the way it works.

26:30 – How To Plan New Complement Analysis

Kyowa SSW 2023 Panel: Branded Components and Collaborative Competitors with Dan, Joey, and Chris of Ghost, Glaxon, and Nutrabolt

Taking Joey’s anti-microplastics probiotic concept for example, how does one go about planning the scientific analysis wanted to show its efficacy, and convey it to market? There’s a regular sequence – cell research, then rodent research, then human research. Extra particularly, step one is often a Caco-2 cell examine.

One of many questions that wants answering is what the micro organism flip the microplastics into. To ensure that the complement to enhance well being, we have to make sure that the microplastic metabolites aren’t poisonous.

In case you’re fortunate, the microplastic metabolites will take the type of methane, a fartable fuel. Such a metabolite could be preferable to, say, CO2, which might trigger well being points if it builds up.

Taking pictures from the intestine, Joey’s estimating that 20% lower in microplastic content material could be a superb place to begin by way of the probiotic’s efficacy.

29:00 – Benefits of Probiotics and Actual-World Precedents

On the subject of probiotic dietary supplements, even comparatively small impact sizes can have large compounding results over time, as a result of as soon as the micro organism take up residence in your intestine, they start working 24/7 to interrupt down microplastics.

Joey factors out that the anti-microplastic probiotic can’t be that far-fetched, since micro organism have already been used for bioremediation after oil spills. Within the Deepwater Horizon catastrophe, for instance, microbes had been used to show polyaromatic hydrocarbons into CO2. Nevertheless, after all, the intestine microbiome is a really totally different surroundings than the floor of the ocean, and a whole lot of work must be executed earlier than you possibly can apply this mannequin to people.

30:00 – Subsequent Analysis Step After Caco-2

As soon as the preliminary cell examine is completed, how do you go about designing a pilot examine in people? This isn’t pharma, so we’re not going to get 12,000 topics. A pattern dimension of fifty is a reasonably cheap place to begin in complement analysis. What actually issues is examine design – there must be a management group. And not using a good examine design, large impact sizes really turn into extra suspicious than smaller ones.

Joey discusses a selected case examine inside a Discord sleep group led by Joey, involving 15 individuals who’ve been observing the impression of dietary supplements on sleep structure for nearly a 12 months. Joey highlights fascinating findings associated to seasonal modifications in sleep patterns, noting variations in REM and deep sleep throughout seasons and its potential implications on temper and cognitive features, moderately than simply attributing seasonal temper variations to vitamin D or climate modifications alone.

34:00 – Digital Biomarkers

Mike discusses the potential for participating podcast listeners as topics for beta testing dietary dietary supplements and merchandise. Joey shares insights from a category on AI in prescription drugs and biotech at MIT, highlighting the significance of digital biomarkers, equivalent to these collected from smartwatches and different IoT units, in learning interventions like sleep or train.

Ben mentions his expertise with a WHOOP gadget, noting its accuracy but in addition questioning the utility of the huge quantity of information it supplies for people who’re already in tune with their our bodies.

35:40 – Hashish and Melatonin

Ben shares his expertise of bettering his deep sleep by stopping hashish use inside 5 hours earlier than bedtime, regardless of the frequent perception that it aids sleep. Joey explains the significance of balancing REM and deep sleep, highlighting deep sleep’s essential function in longevity, cell restore, and reminiscence consolidation.

They focus on methods to boost sleep high quality, together with spacing sleep aids, alcohol, and hashish from bedtime, and utilizing melatonin in microdoses moderately than giant quantities. Joey suggests taking sleep aids or substances like melatonin just a few hours earlier than mattress to permit for pure sleep that maximizes deep sleep.

39:15 – BHB in drinks?

Mike, Joey, and Ben focus on a brand new beverage they’re consuming, which comprises a novel type of BHB (Beta-Hydroxybutyrate) developed by Ketone Labs. This BHB variant is 50% free acid, that means it could possibly now be utilized in drinks. Joey mentions the ingredient’s potential to be used in non-caffeinated vitality drinks, highlighting its advantages for individuals who have reached their caffeine restrict however nonetheless search an vitality increase with out the standard caffeine crash. They categorical pleasure about upcoming collaborations and potential podcasts with the founding father of Ketone Labs at Expo West.

42:15 – Caffeine vs. BHB and BHB with Carbs?

goBHB was consumed throughout this podcast

Joey explains his private caffeine consumption technique, limiting himself to 320 milligrams per day, break up between his wake-up routine and lunchtime, then switching to BHB (Beta-Hydroxybutyrate) for sustained vitality. He mentions current intestine microbiome changes which have lowered his want for the second caffeine dose, permitting him to rely solely on BHB. The dialogue then shifts to the broader utility of BHB past simply ketogenic diets, emphasizing its potential as a sustained vitality supply when transitioning off caffeine.

Joey discusses the challenges of utilizing BHB salts in merchandise resulting from their instability in low pH environments and the potential for inflicting explosive diarrhea as a result of excessive mineral load. He recounts an expertise from 2017 with a BHB ready-to-drink product that led to gastrointestinal points when consumed in extra.

The dialog then shifts to combining BHB with carbohydrates for enhanced efficiency throughout exercises, with Joey recommending a one-to-one ratio to start out. He notes the significance of contemplating the kind of carbohydrates used, mentioning a mixture that features ribose, cyclodextrin, and maltodextrin, and the exploration of various ratios for optimum efficiency. The dialogue briefly touches on using trehalose, impressed by its use in water bears to forestall dehydration.

49:30 – Tardigrades

Joey introduces the idea of tardigrades, microscopic organisms recognized for his or her resilience. Tardigrades, also known as “water bears” resulting from their look, are able to surviving in excessive environments, together with the vacuum of area. The hosts counsel trying up tardigrades on-line to get a visible understanding of those distinctive creatures, noting their distinct look that may be each cute and unsettling. Joey explains that tardigrades use substances like trehalose and glycerol to guard themselves from harsh environments, highlighting these compounds’ fascinating properties.

The dialog then shifts to using trehalose in human diet, notably for athletes, resulting from its twin goal of fueling the physique and aiding hydration. Joey emphasizes the significance of understanding there are different carbohydrate sources accessible, equivalent to trehalose, for particular makes use of like endurance sports activities to take care of hydration alongside gas provision.

53:45 – Carbs and electrolytes

Joey discusses the connection between carbohydrates and electrolyte absorption, highlighting the glucose dependency of sodium chloride transporters. He means that even a small quantity of carbohydrates can improve the effectiveness of hydration merchandise by facilitating mineral absorption. Joey explains that whereas consuming electrolytes throughout a exercise might not require further carbohydrates for individuals who have a balanced eating regimen, together with carbohydrates in hydration merchandise can function a precaution, particularly for these working towards fasted cardio or intermittent fasting.

56:45 – Potassium

Joey talks about using potassium gluconate in hydration formulation, noting its absence seemingly resulting from potential gastric upset and its look as a less expensive, much less widespread possibility in sports activities diet. He explains that many formulation go for potassium sources like potassium citrate or chloride, or substances like coconut water, for his or her potassium content material. Resulting from potassium’s gastrointestinal dangers, Glaxon took a extra aware method when designing Astrolyte.

Joey additionally feedback on the product Prime which has a extremely skewed ratio of potassium to sodium, attributing this imbalance to a reliance on coconut water and a scarcity of thorough consideration in system design. He means that, though not revolutionary, the method is comparatively protected, given the overall potassium deficiency within the American eating regimen and the larger well being dangers related to extreme sodium consumption.

1:00:35 – Potassium issues

This paper’s title is so spectacular that it deserves its personal call-out.[3] So what provides? We concurrently imagine that sodium suggestions can go larger, however potassium does should be supplemented in fashionable dieters as properly.

Joey shares anecdotes and insights in regards to the potential GI discomfort from extreme potassium consumption, highlighting the significance of steadiness in electrolyte consumption. The dialog additionally touches on the broader context of dietary habits, suggesting that some potassium supplementation could be useful given the excessive sodium consumption from processed meals prevalent in lots of diets. Moreover, there’s a humorous alternate in regards to the significance of discussing bowel actions within the context of well being and cleansing.

1:03:15 – Fiber Fusion

Joey discusses Glaxon Fiber Fusion, designed for use alongside a sleep support like Tranquility for improved digestive well being, emphasizing the significance of a morning bowel motion as a part of an ideal night time’s sleep.

He shares findings from surveys about bowel motion habits, highlighting that most individuals are likely to have their bowel actions within the morning, partly as a result of results of gravity and posture change.

1:07:00 – Fiber and psyllium husk

Joey mentions that fiber dietary supplements in capsule type should not ultimate as a result of giant doses required for effectiveness. There’s a dialogue in regards to the potential dangers of psyllium capsules increasing within the esophagus and the choice for consuming psyllium husk powder with water to keep away from gastrointestinal points like acid reflux disease.

The group additionally touches on the significance of timing fiber consumption individually from different dietary supplements to keep away from interference with absorption, highlighting how fiber can decelerate the discharge and delay the effectiveness of different ingested substances. Joey notes that some corporations are exploring fiber blends with dietary supplements like melatonin to create time-release results.

1:08:45 – Niacin and The Flush

Joey discusses his use of two grams of niacin, considerably greater than Mike’s 100 milligrams, highlighting the transformative expertise of a niacin flush. Joey describes the niacin flush as proof of dietary supplements’ effectiveness, detailing the method from the onset to the afterglow and improved peripheral blood circulate.

The NAD Pathways, in blue.[4] * Within the description above, we point out that there are 4 recognized pathways. That is counting the 2 totally different salvage pathways on the underside individually.

The dialog additionally touches on Paul Stamets’ suggestion to mix niacin with psilocybin and Lion’s Mane for enhanced peripheral motion. Joey advocates for enduring the extreme expertise of a high-dose niacin flush as a journey by means of numerous states of discomfort and satisfaction.

Joey discusses the best way to mitigate the niacin flush or adapt to larger doses, suggesting that over time, with constant use, one’s physique might adapt and not expertise the flush even at doses like two grams. He mentions that doses round 800 milligrams had been utilized in medical research for NAD+ replenishment and that doses as much as three grams may have an effect on insulin sensitivity negatively.

Joey additionally touches on utilizing niacin for lipid and ldl cholesterol modulation. The dialog briefly explores the thought of mixing niacin with different dietary supplements and experiences, like sauna use, to boost cleansing results, with a notice on balancing consumption and cleansing for total well being.

1:14:00 – Niacin Pre-Exercise and Lowered Efficiency

Joey discusses a examine that prompt pre-workout niacin supplementation may lower efficiency, probably resulting from lowered lipid circulation. He explains the mechanism by which niacin reduces ldl cholesterol and triglycerides as a “parlor trick” that indicators the physique to retailer these substances in cells, successfully clearing the blood.

This mechanism can also be talked about within the context of utilizing niacin to cross THC drug assessments by quickly eradicating fat from the bloodstream. Joey notes that whereas this technique can work, it isn’t at all times dependable.

1:16:00 – Passing THC Assessments?

Joey humorously discusses a novel technique for passing THC drug assessments involving bodily exercise to liberate THC saved in fats cells, adopted by consuming high-fat meals to create a brand new layer of fats to “bury” the THC.

The dialogue additionally covers using niacin together with this technique to boost the impact. They discover the potential for experiencing a excessive from launched THC throughout bodily exercise and focus on the theoretical elements of THC storage and turnover in fats cells.

1:20:15 – Hashish enhancement complement

Joey expresses curiosity in exploring the entourage impact with endogenous cannabinoids and discusses his experimental complement, the “Canna Cascade,” which goals to boost the consequences of hashish. He mentions how sure fat, together with arachidonic acid, play a task in cannabinoid receptor modulation, enhancing the efficiency of hashish.

The dialog touches on the potential for such a complement to be marketed, contemplating the authorized and regulatory challenges related to making claims about its results. Joey and the hosts focus on the viability of promoting such merchandise in dispensaries or head retailers as a technique to leverage dietary complement data within the context of leisure drug use.

1:23:30 – Microplastics

The dialogue turns to the problem of microplastics and their pervasive presence in day by day life, from meals packaging to utensils. Joey highlights the ever present use of plastic in meals containers and the potential well being dangers related to microplastic consumption. He means that whereas capsules could be a safer possibility resulting from their inert supplies, powders may work together with their plastic packaging or shaker cups, probably resulting in microplastic contamination. The dialog additionally touches on the logistical challenges of avoiding plastic, like the problem of discovering non-plastic alternate options for product packaging and the significance of being conscious of those points with out essentially ceasing complement use.

1:25:45 – Meals supply adaptation

The dialogue shifts to quite a lot of matters, together with a pattern of a product referred to as Ketonella, prompting the group to surprise if Nutella could have a difficulty with the identify.The group talks in regards to the resilience of 1’s digestive system to totally different meals and touches on dietary flexibility and preparedness for provide chain disruptions, suggesting the significance of having the ability to adapt to totally different meals sources.

1:28:00 – The state of the complement business

The NPA (Pure Merchandise Affiliation) has introduced their annual Washington DC Fly-In Day for 2024: Might 22! Be part of us and assist the dietary complement business.

The dialog shifts to future plans, with Joey expressing a need to be extra concerned within the business on a broader scale, probably by means of actions like fundraising for business causes and becoming a member of occasions like NPA’s Fly-In Day to advocate for the business’s pursuits.

There’s additionally a dialogue in regards to the significance of unity inside the business to deal with regulatory challenges successfully. Mike brings up the thought of lobbying efforts and speculates about potential conferences with politicians like Senator Marco Rubio and Senator Ted Cruz by means of business associations just like the NPA. Joey responds that he doesn’t suppose these senators “give a f*ck” about dietary supplements. Ben agrees, however says that they do bear in mind 2020 and NAC getting hit. He thinks that individuals perceive well being greater than ever and that it’s about connecting dots for them.

1:30:45 – A brand new technology of complement business leaders

Joey talks about how we’re experiencing the growing older of the most important technology ever seen, and the proliferation of non-communicable metabolic illnesses on account of life-style and environmental components. Between alcoholic, sedentary existence, weight problems, smoking, and extra, normal well being is on the precipice of whole collapse.

Quite a lot of these components may have been averted with correct diet, and Joey thinks Gen Xers and onwards are extra acutely aware of this resulting from athletic heroes and cultural icons. Joey acknowledges that a lot of them are on gear, however maintains that the subsequent technology of politicians could also be extra amenable to discussions about dietary dietary supplements.

Joey desires to take a seat in entrance of the opposition of the business and ask for some form of dialogue and center floor.

1:35:00 – The regulatory battleground

Ben mentions that once they go to DC and meet with NPA, that’s the time to speak to your representatives, however that there are at all times alternatives to speak to representatives on a state and native degree.

Discussing states, Joey says that he doesn’t suppose Texas, Florida, and Utah are an issue. States like Rhode Island, New Jersey, New York, California, and extra are the issue. The group makes an attraction to the viewers to get involved, and to ask how they’ll become involved. Whereas most of the staunch business opponents gained’t reply to purpose, they’ll reply to pressure (i.e. being a ache).

Mike asks what prompted Joey to become involved, and he stated that NMN was the primary powder keg for him. It’s a B vitamin (as described in our NMN FDA breakdown), and the egregious oversteps by regulators signaled a significant step out of bounds.

1:41:30 – The hazard of precedent

Ben is nervous about precedent. He brings up CBD, and its pharmaceutical function. In consequence, due to the struggle on medication, the complement business by no means had an enormous alternative to discover and analysis it.

Ben says that drawing clear traces is important, and Mike hopes these traces will come out of the authorized actions being undertaken by NPA.