C4 Ultimate Strength – Bringing Peptides to a Pre-Workout

There’s presently one actually sizzling buzzword within the complement and pharmaceutical industries alike. That phrase is peptides.

Because of breakthroughs in computing energy and statistical evaluation, science has now recognized hundreds of amino acid chains which have outsized results on vital facets of human physiology.

Final 12 months we wrote rather a lot about PeptiStrong, a fava-bean-derived peptide community that has some unbelievable pro-anabolic results. PeptiStrong was developed by Nuritas, a biotech firm that used synthetic intelligence to search out the perfect supply for the peptides they sought.

However now, due to Nutrabolt, one other Nuritas peptide has hit the market, and it’s in a pre-workout sequence we’ve all come to respect:

C4 Final Energy – A Highly effective Pre-Exercise with PeptiStrong and PeptiPump

The product line we’re speaking about is C4 Final, and the product we’re particularly zeroing in on in the present day is C4 Final Energy, which, to us, is essentially the most thrilling pre-workout of all the ones we’ve seen in Nutrabolt’s new C4 fifth Technology Launch of 2024.

That is partly as a result of it consists of PeptiPump, a peptide community centered on creating huge pumps by means of vasodilation, along with the PeptiStrong that was within the earlier technology.

So now we’re getting each of those unbelievable peptides in the identical product.

The discharge of this C4 technology is a watershed second for the dietary complement business. It marks the start of what we expect is destined to be a really lengthy and really rewarding chapter in complement science – the period of peptide dominance.

In fact, peptides aren’t the one factor in C4. This method additionally options a formidable array of acquainted nutraceuticals and botanical extracts.

Let’s get into how this works, however first, test the PricePlow information and offers:

C4 Final Energy Elements

In a single 27.5 gram (1 scoop) serving of C4 Final Energy, you get the next:

Endurance & Efficiency Advanced – 10,650 mg

CarnoSyn Beta-Alanine – 3,200 mg

Beta-alanine is likely one of the complement business’s favourite ergogenic aids – an ergogenic support being outlined as any substance, machine, approach, or remedy that enhances a person’s power utilization, effectivity, or efficiency throughout train.

Along with the amino acid L-histidine, beta-alanine is a precursor to a dipeptide molecule referred to as carnosine, which the physique makes use of to detoxify lactic acid in muscle tissue.[1] Since lactic acid (AKA lactate) accumulation is a serious driver within the onset of muscular fatigue, slowing down its constructing by way of beta-alanine supplementation is an efficient endurance-boosting technique.

The peer-reviewed literature signifies that supplementing with beta-alanine can enhance athletic efficiency by extending a person’s time to exhaustion,[2,3] growing energy,[4] and, when taken long run, encouraging a lean physique composition.[5]

Two huge meta-analyses of the literature on beta-alanine discovered that for a lot of completely different sorts of train and sports activities efficiency, a every day 3,200 mg dose of beta-alanine can vastly improve endurance and cut back fatigue. Nevertheless, it seems that beta-alanine does this finest for train performed at a selected stage of depth – that which may be sustained for 30 seconds to 10 minutes.[1]

Why we like CarnoSyn

CarnoSyn, a patented formulation of beta-alanine, has been developed and marketed by Pure Options Worldwide. Widely known throughout the complement business for its superior high quality, it stands out as one of many premier manufacturers of beta-alanine accessible.

Pure Options maintains a strict coverage of high quality management, licensing the usage of their elements solely when appropriately dosed. This dedication to high quality is obvious in C4, the place customers profit from the clinically-validated 3,200 mg dose.

VELOX patented efficiency mix

VELOX is a mix of amino acids patented[6-9] by the Kyowa Kirin firm — right here in America, we work with Kyowa Hakko USA, they usually truly manufacture Velox proper right here within the states in Missouri! In case you don’t know, Kyowa is famend for the purity and high quality of its amino acid dietary supplements, and truly pioneered a technique of amino acid fermentation that’s now the business customary.

The concept behind combining these two particular aminos, specifically citrulline and arginine, that they’ve a synergistic impact in your physique’s manufacturing of nitric oxide (NO).[10-12] That’s, the mixture of those aminos works higher to upregulate NO than both one alone.

The fundamental motive for that is that citrulline inhibits an enzyme referred to as arginase, which ordinarily degrades arginine earlier than it may be digested and absorbed by the physique.[13] This makes arginine more practical, plus, as we’ll see, citrulline has NO-boosting results of its personal.

L-Citrulline – 3,000 mg

Citrulline is classed as a non-essential amino acid, which signifies that your physique could make citrulline by itself, as long as it’s equipped with the mandatory chemical precursors. The catch is that there’s a restrict on how briskly your physique can synthesize it – and the quantity you want, particularly below circumstances like damage or sickness, dramatically outstrips your physique’s means to make it.

So how does citrulline work? It will increase your physique’s means to synthesize nitric oxide (NO).[2] Though arginine was truly the usual NO-boosting ingredient for a very long time, citrulline progressively supplanted it owing to the later’s superior oral bioavailability.[3] However like we stated above, the mixture of citrulline and arginine makes arginine more practical, by inhibiting arginase and sparing arginine from the primary move impact.[4]

The rationale we wish extra NO is that NO triggers vasodilation, a phenomenon the place your arteries develop in diameter, permitting a higher quantity of blood to movement by means of them, and bettering supply of blood to microvessels which are delicate to modifications in circulatory standing.

With circulation improved, oxygen and vitamins can attain your cells extra effectively, main to higher athletic efficiency. On the similar time, the improved circulation additionally helps your physique do away with metabolic wastes like lactic acid, resulting in improved restoration from train.

It’s no surprise, then, that research on citrulline have demonstrated its means to:

Enhance mobile oxygen utilization, thus bettering efficiency at max depth[5]
Delay athletic endurance – one research discovered that citrulline dietary supplements enabled topics to carry out 53% extra bench press reps than the placebo group[14]
Lower post-exercise soreness, by roughly 40%.[14]

L-Arginine – 3,000 mg

So what advantages does arginine give us? Since your physique truly converts citrulline into arginine earlier than the arginine will get was NO, it’s secure to say that each one the advantages of citrulline supplementation are related to arginine as nicely.

Right here’s what the complete conversion pathway seems to be like:

Citrulline → Arginine → NO

With this mix of amino acids, you’re undoubtedly getting tons of NO upregulation.

An ingredient made within the USA!

You possibly can examine Kyowa Hakko USA’s American facility in our article titled “Kyowa High quality: Trusted Complement Elements Made within the USA“ and “Amino Acids Made within the USA: Kyowa High quality’s Citrulline, Glutamine, and Arginine“. We love that Nutrabolt is leaning into this American-made ingredient duo!

BetaPower Betaine Anhydrous – 1,250 mg

Betaine, AKA trimethylglycine (TMG), is an ergogenic support like beta-alanine, however it makes use of a definite mechanism of motion.

Methyl donor

“Ergogenic support” is a fairly broad class, and there are lots of completely different mechanisms of motion that may create an ergogenic impact. One of the crucial frequent, although, is the flexibility to extend your cells’ manufacturing of adenosine triphosphate (ATP), the power foreign money that your cells use to carry out all their metabolic duties. You possibly can consider ATP as your cells’ gasoline, so it ought to make intuitive sense that giving them extra ATP can translate to improved cognition and higher athletic and cognitive efficiency.

And because it seems, that is exactly what betaine does – it upregulates ATP by enhancing mitochondrial respiration.[15]

Betaine will increase ATP synthesis by donating methyl teams (chemical method CH3) to websites within the physique the place these methyls are required for the efficiency of important mobile features.[16] In actual fact, amongst all methyl donors identified to science, betaine is likely one of the most potent.[17]

Certainly one of methyl group’s most important roles helps the physique regulate blood ranges of homocysteine, an amino acid that’s generated when your physique metabolizes one other amino acid referred to as methionine. If homocysteine ranges rise too far, the result’s a considerably elevated threat of heart problems,[18] so we wish to maintain that below management as finest we will.

Since homocysteine regulation is very depending on methylation, betaine dietary supplements can considerably lower blood homocysteine.[19] This implies betaine supplementation could be a nice funding in your long-term cardiovascular well being and athletic efficiency.

Osmolyte results

Methyl donation isn’t the one means that betaine can enhance efficiency, although. It’s additionally an osmolyte, that means it might positively have an effect on mobile water stability.

Extra particularly, betaine can push further water into your physique’s cells, resulting in a fascinating state referred to as mobile hyperhydration, through which cells profit from improved nutrient availability[20,21] and are extra immune to the debilitating results of warmth.[22]

Betaine research

At 2.5 grams or extra (which we don’t have right here), the peer-reviewed literature on betaine exhibits that it might:

Enhance energy[23,24]
Enhance energy[22,23,25-27]
Enhance physique composition[21,28,29]

In a single significantly spectacular research, collegiate ladies who took betaine alongside weight coaching misplaced 4 kilos extra physique fats than the placebo group.[28]

So with that stated, we’re going to need to look ahead to a Nutrabolt-led muscle builder to assist high off the 1.25 grams inside right here.

PeptiPump Bioactive Lentil Peptides – 200 mg

PeptiPump is a novel peptide community recognized and remoted from lentils, by Nuritas with the help of AI-driven analysis instruments. It consists of peptides which were proven to inhibit angiotensin-converting enzyme (ACE), a mechanism with vital vasodilatory results. This mechanism’s decrease blood strain is why pharmaceutical ACE inhibitors are a prescription remedy for hypertension.

As a result of ACE inhibition is such a strong technique for growing muscle blood movement and oxygenation, food-derived ACE-inhibiting peptides have lengthy been mentioned as a potential software for bettering circulatory dynamics.[30-32] The large challenge that wanted to be solved was bioavailability – and PeptiPump seems to have solved that drawback, because it’s been proven to outlive gastrointestinal digestion and absorption.[33,34]

That is Nuritas’ complement to PeptiStrong, a extra anabolic-focused peptide that we’ll be discussing under.

As of March 2024, we nonetheless don’t have any peer-reviewed, journal-published analysis on PeptiPump itself. Nevertheless, Nutrabolt and Nuritas launched an announcement explaining what the ingredient was, and we posted it in our article titled “PeptiPump: A Lentil Protein Hydrolysate Containing Bioactive Peptides“.

A research printed in 2023 titled “Growth of lentil peptides with potent antioxidant, antihypertensive, and antidiabetic actions together with umami style”[35] discusses a few of the underlying analysis that could be at play right here, however we look ahead to analysis particularly carried out on PeptiPump itself. When it’s out, we’ll replace the article linked above.

Muscle & Energy Matrix – 8.05 grams

Creatine monohydrate – 4 grams

Though we haven’t run the numbers, we’re prepared to wager that extra papers have been written about creatine than every other dietary complement.

The reason being easy – creatine works, and it really works nicely. Keep in mind what we wrote within the betaine part about creating ergogenic results by means of ATP upregulation? Nicely, that’s precisely what creatine does, too.[36-39]

Rising ATP shops, and therefore mobile power availability by way of creatine supplementation has been proven to do the next:

Enhance energy[40,41]
Promote muscle acquire[42-45]
Enhance dash pace[46-48]
Increase mobile hydration[49]
Cut back fatigue[50-52]
Enhance sense of general well-being[53-55]
Improve cognitive efficiency[56,57]
Enhance serum testosterone[58-62]

In addition to the few dozen research we’ve coated on this spectacular listing, there are, with out exaggeration, tons of of comparable peer-reviewed research and meta-analyses all displaying the identical factor: creatine is a completely kickass complement for efficiency, each psychological and bodily.

The 4 gram dose is sufficient – and now we have extra coming from creatine nitrate!

You’ve in all probability observed that Nutrabolt C4 makes use of 4 grams of creatine, as a substitute of the same old 5. Don’t fear, although – there are two issues taking place right here.

First, now we have extra creatine coming from the 1.5 grams of creatine nitrate, which can fill in that fifth gram.
However even when that weren’t the case, that is nonetheless an efficacious dose! Knowledge from the Nationwide Well being and Diet Examination Survey (NHANES) signifies that Individuals get, on common, 0.54 grams of creatine per day from meals, with a median every day creatine lack of 2 grams per day.[63]

Which means even should you bought zero grams of creatine per day from food regimen, a 4-gram dose would nonetheless be twice as a lot as you should cowl your every day creatine necessities. But Nutrabolt didn’t go away that to probability, they proceed to depend on creatine nitrate which brings creatine alongside the nitrate-based pumps.

Backside line, this dose by itself works nice, however C4 Final Energy isn’t achieved but — there’s extra creatine on the way in which.

PeptiStrong bioactive fava bean peptides – 2,400 mg

Whereas PeptiPump is concentrated on enhancing blood movement, PeptiStrong is Nuritas’ extra anabolic peptide community.

Now that we’re speaking about anabolic mechanisms and muscle development, we ought to be cautious to differentiate between dietary protein and peptides. Whereas peptides are technically proteins, we use the time period peptide as a form of short-hand to seek advice from proteins which were recognized for his or her informational results on human physiology. By altering epigenetic and hormonal components, peptides can have dramatically non-linear results on human well being.[64-66]

By manipulating these key bio-informational levers by means of peptide supplementation, we may also help alter physique composition with out counting on modifications to caloric consumption.

And that’s precisely what PeptiStrong has been proven to do. It’s made up of over 400 completely different peptides[67] that had been chosen for his or her means to upregulate mammalian goal of rapamycin (mTOR), a change that controls the synthesis of latest muscle tissue.

Human research 1: PeptiStrong’s can improve energy good points throughout restoration from muscle injury

In a randomized, double-blind, placebo-controlled research from 2023, researchers recruited 30 wholesome, recreationally-active males between the ages of 30 and 45. Topics accomplished a baseline energy take a look at on day 1 of the research interval, and had been then given both 2.4 grams of PeptiStrong or a placebo each day for 2 weeks.[68]

On day 15, topics stopped their prescribed remedy, after which accomplished a followup bodily health evaluation, which consisted of a stationary bike warmup, adopted by a knee flexion and extension take a look at designed to measure knee energy. The take a look at consisted of 5 warmup reps, progressively growing from 60% to 100% of the themes’ most effort, adopted by 2 units of 5 reps carried out at 100% effort.[68]

This explicit leg train is understood to trigger vital muscle injury,[69,70] making it a really perfect take a look at to make use of for the aim of assessing muscle development and restoration.

The research authors examined the themes’ restoration progress by analyzing quite a lot of biomarkers 48 and 72 hours after the preliminary take a look at day – that’s, the seventeenth and 18th days of the overall research interval – whereas the supplementation routine resumed.[68]

On the 72 hour mark, the research authors discovered one thing astonishing – the PeptiStrong group had not solely absolutely recovered from the muscle injury brought on by the take a look at, however had truly elevated their energy above the baseline! By comparability, the placebo group had, at this level, not even absolutely recovered their baseline stage of energy.[68]

Furthermore, the PeptiStrong group scored considerably higher on a fatigue index, which signifies a major improve in muscular endurance.[68]

Lastly, key biomarkers like myokine exercise indicated that the PeptiStrong group had a heightened inflammatory response post-workout, which is a interval the place irritation can truly profit the anabolic response.[68]

Much more wonderful is PeptiStrong’s impact on myostatin, a protein that’s identified to inhibit muscle protein synthesis:

The potential significance of that is exhausting to overstate – sports activities diet has been making an attempt for many years to determine a viable myostatin inhibitor, which holds such unbelievable anabolic promise that it’s the closest factor this business has to a holy grail. For sure, it’s completely wonderful that we could lastly have one in PeptiStrong.

Restoration after immobilization-induced muscular atrophy

One other research, additionally from 2023, checked out PeptiStrong’s means to keep up muscle tissue throughout compelled immobilization. On this research, 30 younger males had been recruited to put on a plaster forged for 7 days. Since this forged fully restricted knee flexion, it was a solution to create profound muscular atrophy within the affected leg.[71]

The research contributors had been randomized to take both 20 grams of PeptiStrong or 20 grams of milk protein every day. The concept behind this research design is to reveal PeptiStrong’s disproportionate results on muscle development by dose-matching it with an peculiar dietary protein.

The researchers discovered that, as soon as the casts got here off, the PeptiStrong group recovered misplaced muscle 4 instances sooner than the milk protein group![71]

Even if each teams skilled roughly the identical extent of muscle loss, as soon as the themes had been capable of transfer their legs, the PeptiStrong group recovered far sooner.

Creatine Nitrate (as NO3-T) – 1,500 mg

Creatine nitrate comes with all the advantages of creatine that we mentioned within the creatine monohydrate part, plus the advantages of nitrates. C4 is well-known for his or her use of creatine nitrate, and we’re pleased they saved it within the fifth Technology. This concurrently will get us as much as about 5 grams of creatine, but in addition provides within the pumps from the nitrate facet:

Advantages of nitrates

Nitrates are fascinating for a similar motive as citrulline and arginine – they assist the physique create NO, albeit by a barely completely different pathway. When nitrates are ingested, oral micro organism chemically cut back these nitrates to nitrites. When blended with saliva, these nitrites can convert to nitric oxide within the acidic surroundings of the abdomen and gastrointestinal tract, facilitated by enzymes like salivary peroxidase.[72-74]

As a result of supplemental nitrates can improve NO manufacturing, they arrive with the same old NO-related advantages:

Higher circulation[75]
Elevated cardio effectivity[75-78]
Elevated energy[79,80]
Enhanced mobile power manufacturing[80-82]

Research carried out particularly on creatine nitrate

As for creatine nitrate itself, there are research displaying that it might help vital will increase in bench press energy,[83-85] leg press energy,[84] and leg press endurance.[84]

Moreover, it additionally has a terrific security profile,[83,86] which isn’t stunning given its mechanisms, ATP-boosting capabilities, and the truth that Nutrabolt has lengthy relied on the ingredient with out issues!

elevATP Historical Peat and Apple fruit extract – 150 mg

ElevATP is made up of polyphenol antioxidants derived from historical peat moss and apples, and recognized for his or her means to extend adenosine triphosphate (ATP) manufacturing.[87]

We love elevATP as a result of, as we mentioned earlier, ATP is crucially vital for well being and efficiency. Because it’s the type of power your cells truly use, your physique’s means to provide these cells with ATP is a potential bottleneck on athletic efficiency. In these instances, dietary supplements like elevATP can enhance efficiency.

One 2016 research confirmed that contributors who took 150 milligrams of elevATP for 2 months gained extra energy, leap pace, and energy, in comparison with a placebo.[89] Because the research authors level out, ATP’s means to induce vasodilation is a key mechanism behind these results.[89]

Final Vitality, Focus & Stimulant Matrix – 1.366 grams

The bodily facet of issues is, in spite of everything, solely half of an excellent exercise – to really feel and carry out your finest within the gymnasium, it’s vital to have your temper, power, and focus down as nicely. That’s what this mix is designed that will help you obtain.

L-Tyrosine – 1,000 mg

The amino acid tyrosine is a good complement for serving to handle the stress of coaching and physique recomposition.

Tyrosine serves as a constructing block for catecholamine neurotransmitters resembling dopamine, adrenaline, and noradrenaline,[90-92] that are all essential gamers in regulating focus, motivation, and power ranges. Moreover, adrenaline and noradrenaline play a job in urge for food suppression,[93] doubtlessly aiding in making dietary restrictions extra manageable.

Moreover, tyrosine can improve your thyroid’s manufacturing of the hormones triiodothyronine (T3) and thyroxine (T4).[94,95] That is doubtlessly an enormous deal since weight-reduction plan and train are each aggravating,[94,95] and the mixture of those behaviors may be significantly unhealthy.

Maintains cognition throughout sleep deprivation

Everyone knows that nothing can tank your bodily efficiency – or your means to construct muscle – fairly like sleep deprivation.

Sadly, not getting sufficient sleep can actually hammer your mind too, and compromise cognitive efficiency. However fortuitously, tyrosine may also help with this – in accordance with analysis carried out by the U.S. navy, tyrosine is definitely higher at restoring sleep-deprived individuals’ cognitive skills to baseline than caffeine.[96,97]

Caffeine Anhydrous – 300 mg

Caffeine is a methylxanthine stimulant able to crossing the blood-brain barrier,[98] which supplies it a excessive diploma of exercise within the central nervous system.

Because the overwhelming majority of us know from intimate private expertise, caffeine is nice for bettering temper, enhancing focus, optimizing athletic efficiency, and making the consumer really feel extra energetic.[99] Caffeine’s major energizing mechanism is definitely higher understood as an anti-fatigue mechanism – it inhibits the motion of adenosine, a chemical that builds up within the mind whereas we’re awake and creates psychological fatigue.[100,101]

Nevertheless, caffeine does additionally give us extra power in essentially the most literal potential sense of the phrase – it helps your cells produce extra mobile power by inhibiting an enzyme referred to as phosphodiesterase, which is liable for degrading a messenger molecule referred to as cyclic adenosine monophosphate (cAMP).[99-103]

Caffeine can even allow you to burn fats,[104] as much as 50% sooner than regular.[105] A 2020 meta-analysis of 19 research concluded that measurable upticks in fats oxidation may be noticed with doses as small as 3 milligrams of caffeine per kilogram of body weight.[106]

On the sports activities efficiency facet of issues, caffeine supplementation can improve energy, energy, pace, and endurance.[99,100,102,104,105] Cognitively, caffeine may also help improve consideration, alertness, response time, and dealing reminiscence.[107-109]

Dynamine (as Methylliberine) – 50 mg

Dynamine is a trademarked type of methylliberine, an alkaloid that naturally happens in Camellia sinensis (tea) leaves[110,111] and may exert stimulant results with out inflicting cardiovascular results like vasoconstriction.[110-113] Very similar to caffeine, methylliberine can upregulate dopamine and noradrenaline whereas antagonizing adenosine.[110-113]

In case you want a refresher on how adenosine antagonism works, scroll again as much as the caffeine anhydrous part of this text.

In our anecdotal expertise, Dynamine tends so as to add some “pop” to pre-workout formulation, placing Nutrabolt C4 a reduce above the competitors. It’s typically paired with its counterpart under:

TeaCrine (as Theacrine) – 10 mg

Theacrine is one other alkaloid and shut chemical cousin of caffeine.[114] Like caffeine, it’s a potent stimulant, and happens naturally in Camellia kucha, a standard Chinese language tea selection identified colloquially as simply kucha.[115] Additionally like caffeine, theacrine can improve your psychological and bodily power by antagonizing adenosine[116] and inhibiting the enzyme phosphodiesterase.[117] Theacrine can also be dopaminergic,[118] making it nice for enhancing focus, motivation, and psychological power.

The place theacrine differs from caffeine is in its pharmacodynamics – a small however compelling physique of analysis signifies that in contrast to caffeine, persistent theacrine use doesn’t produce drug tolerance.[118]

Maybe essentially the most intriguing proof of theacrine’s ergogenic impact comes from a 2019 research the place theacrine boosted time to exhaustion at 8% VO2max by 27-38%.[119]

Theacrine additionally appears to be a type of liver tonic, as demonstrated in an animal research the place it attenuated stress-related liver injury.[115]

There’s an excellent little bit of synergy on theacrine, methylliberine, and caffeine,[120-122] and we’re excited to see them mixed. Be aware, nonetheless, the three research cited right here utilizing all of them collectively had completely different doses.

Toothed Clubmoss (Huperzia serrata) aerial components extract (std. 1% Huperzine A) – 5 mg

Huperzine A, an alkaloid derived from Huperzia serrata, acts as a potent inhibitor of acetylcholinesterase, the enzyme accountable for breaking down the neurotransmitter acetylcholine (ACh).[123] By extending the motion of ACh by means of acetylcholinesterase inhibition, Huperzine A will increase its effectiveness.

Right here at PricePlow, we regularly seek advice from ACh as the educational neurotransmitter due to the important thing position it performs in studying and reminiscence consolidation.[124] When ACh ranges improve, it improves all kinds of cognitive features, starting from studying and reminiscence to stability and coordination.[125,126]

Huperzine A can even promote neurogenesis, the formation of latest neurons.[127]

Rauwolfia vomitoria root bark extract – 1 mg

Rauwolscine is a compound discovered within the plant Rauwolfia serpentina, often known as Indian snakeroot. It’s chemically much like yohimbine, and typically known as alpha-yohimbine.

Like yohimbine, rauwolscine is understood for its means to work together with adrenergic receptors within the physique, significantly as an antagonist of the alpha-2 adrenergic receptors. This interplay can have varied physiological results, together with the potential to extend power expenditure,[128] suppress urge for food,[129] and promote fats loss.[130]

On the cognitive facet of issues, rauwolscine’s means to activate the sympathetic nervous system can enhance focus in an enormous means.[131]

Different Elements

In addition to its spectacular array of nutraceuticals and botanical extracts, Nutrabolt C4 additionally has some stable vitamin and mineral help, we’re very pleased they’ve switched to the high-quality B-vitamins in all of their 2024 C4 formulation!

Vitamin B6 (as Pyridoxal-5-Phosphate) – 3.4 mg (200% DV)

Pyridoxal-5-phosphate (PLP) is the energetic type of vitamin B6. Extra particularly, this vitamin features as a coenzyme, which may be transformed into pyridoxamine 5′ phosphate (PMP) as wanted. Collectively, these enzymes coordinate a number of hundred metabolic processes all through the physique, a very powerful of which might be protein metabolism, which may’t happen with out sufficient PLP and PMP.[132]

Vitamin B6 performs an vital position in homocysteine regulation,[132] very similar to betaine (which we mentioned above.)

It’s an vital constructing block for neurotransmitters which are essential for temper, motivation, and perceived power.[132]

Your physique wants B6 to synthesize hemoglobin, which is a fairly large deal for anyone who cares about optimizing athletic efficiency.

Vitamin B6 can even modulate immunity, gluconeogenesis, and glycogenolysis, the chemical degradation of glycogen for usable power.[132]

Supplementing with B6 is related to a decrease threat of heart problems, most cancers, and cognitive dysfunction.[132]

Folate (as 6S-5-Methyltetrahydrofolate calcium salt) – 100 mcg DFE (25% DV)

In comparison with different types of folate (vitamin B9), 5-MTHF exhibits much better bioavailability.[133-135]

Being poor in folate can improve the chance that you just’ll develop the next points:

Excessive homocysteine[136,137]
Fetal delivery defects[138]
Most cancers[139]

This type of folate, 5-MTHF, is a kind your physique can synthesize endogenously from folic acid, by means of the exercise of an enzyme referred to as methylenetetrahydrofolate reductase (MTHFR). One research discovered that as much as 40% of individuals[140] have at the very least one of many genetic polymorphisms that may impair MTHFR functioning, which will increase the provider’s threat of folate deficiency and, thus, elevated homocysteine blood ranges.

Happily, there’s a simple means round this genetic bottleneck – by supplementing straight with the 5-MTHF type of folate, you’ll be able to circumvent the MTHFR enzyme.

Research present that 5-MTHF dietary supplements have the flexibility to:

Elevate blood ranges of folate[133,135]
Decrease blood homocysteine ranges by 14.6%[141]
Enhance the folate content material of crimson blood cells by 23%[141]
Enhance depressive and anxious signs[142,143]

Vitamin B12 (as Methylcobalamin) – 6 mcg (250% DV)

Methylcobalamin is our favourite type of B12 as a result of it’s a methyl donor.[144]

Your physique wants B12 to make crimson blood cells, so lack of B12 could cause megaloblastic anemia, a situation through which crimson blood cells develop bigger however much less quite a few, inflicting an general lower in cardio capability.[145,146]

Vitamin B12 deficiency can also be linked to excessive homocysteine and, in pregnant ladies, elevated threat of fetal delivery defects.[147-149]

EVen gentle B12 deficiencies are linked to compromised reminiscence efficiency,[150] partly due to B12’s impact on homocysteine.[151] However B12 can also be wanted for synthesizing S-adenosylmethionine (SAMe), which is crucial for methylation, myelination, and phospholipid manufacturing within the central nervous system.[151]

Whereas research have but to show that B12 can improve power ranges above baseline, fatigue is a typical signal of early B12 deficiency,[152] and one thing finest prevented.

Sodium (from sea salt) – 225 mg (10% DV)

Though salt has gotten quite a lot of unhealthy press due to its sodium content material, we should always acknowledge that sodium is a necessary electrolyte mineral that’s important for muscle perform, peak efficiency, and restoration.[153] Extreme sodium loss, say from sweating, can compromise these very important facets of well being,[154] so together with a bit of sodium in a pre-workout isn’t essentially a foul thought.

In case you’re nervous about it, simply sweat tougher! Simply kidding – if in case you have considerations in regards to the sodium content material right here, ask your physician.

Calcium – 75 mg (6% DV)

Phosphorus (as dipotassium phosphate) – 75 mg (6% DV)

Magnesium (as magnesium citrate) – 20 mg (5% DV)

Chloride (from Sea Salt) – 340 mg (15% DV)

Potassium (as dipotassium phosphate) – 190 mg (4% DV)

Flavors Out there

Conclusion

This is likely one of the most spectacular formulation we’ve seen in a really very long time, and never simply because it has the peptide double characteristic. Using VELOX exhibits that somebody at Nutrabolt actually did their homework on maximizing the vasodilatory impact of citrulline and arginine. Plus, the nootropic mix right here, with a dizzying array of area of interest alkaloids and ample neurotransmitter help, is totally top-notch.

We love that the pre-workout features a 5 gram whole yield, however doesn’t ditch the creatine nitrate that C4’s turn out to be so well-known for. The one factor you’ll wish to discover is one other 1.25 grams of betaine someplace, actually.

However once more, the peptides are going to essentially push this over the sting into excellent territory.

To be trustworthy, this method could be a steal at nearly any present worth level within the pre-workout class. A should attempt for 2024 and past.