By Dennis Thompson HealthDay Reporter
MONDAY, July 8, 2024 — Mounjaro outperforms Ozempic in serving to folks shed pounds, a brand new research reveals.
Folks taking tirzepatide (Mounjaro, Zepbound) dropped considerably extra kilos than these taking semaglutide (Ozempic, Wegovy), researchers reported July 8 within the journal JAMA Inner Drugs.
“People with obese or weight problems handled with tirzepatide had been considerably extra prone to obtain clinically significant weight reduction and bigger reductions in physique weight in contrast with these handled with semaglutide,” concluded the analysis workforce led by Dr. Nicholas Stucky, vice chairman of analysis with Truveta Inc., a medical analysis collective.
For the research, researchers tracked greater than 18,000 obese and overweight individuals who had been prescribed both drug to assist management their kind 2 diabetes between Could 2022 and September 2023.
Each medication initially had been developed as kind 2 diabetes drugs, however had been later accepted to be used in weight reduction.
Outcomes present that each medication are efficient in selling some weight reduction. Almost 82% of sufferers taking Mounjaro misplaced 5% or extra of their physique weight, in comparison with practically 67% of these taking Ozempic, researchers discovered.
Nonetheless, Mounjaro customers had been extra prone to obtain better weight achieve. About 42% of Mounjaro sufferers misplaced 15% or extra of their physique weight, in comparison with about 18% of these taking Ozempic.
Total, sufferers on Mounjaro had been 76% extra seemingly than these on Ozempic to lose 5% or extra of their physique weight; 2.5 occasions extra prone to lose 10% or extra of their physique weight; and three.2 occasions extra prone to lose 15% or extra of their physique weight, outcomes present.
Mounjaro sufferers additionally skilled bigger reductions in physique weight all through their first yr on the drug, researchers added.
After three months, Mounjaro sufferers had misplaced about 6% of their physique weight in comparison with below 4% for Ozempic sufferers. The distinction was 10% versus 6% at six months, and 15% to eight% at one yr.
Each medication work by mimicking the consequences of the intestine hormone GLP-1, which performs a job in sustaining steady blood sugar ranges. This motion additionally slows digestion and will increase satiety.
Nonetheless, Mounjaro additionally stimulates a second intestine hormone known as GIP, which could clarify the boosted results discovered on this research.
Sources
JAMA Inner Drugs, information launch, July 8, 2024
Disclaimer: Statistical information in medical articles present basic traits and don’t pertain to people. Particular person components can differ tremendously. All the time search personalised medical recommendation for particular person healthcare selections.
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Posted July 2024
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