A long-term ketogenic diet accumulates aged cells in normal tissues, new study shows

A strict “keto-friendly” weight loss program common for weight reduction and diabetes, relying on each the weight loss program and particular person, may not be all that pleasant.

A brand new examine led by researchers at The College of Texas Well being Science Heart at San Antonio (UT Well being San Antonio) discovered {that a} steady long-term ketogenic weight loss program might induce senescence, or aged, cells in regular tissues, with results on coronary heart and kidney perform specifically. Nonetheless, an intermittent ketogenic weight loss program, with a deliberate keto trip or break, didn’t exhibit any pro-inflammatory results resulting from aged cells, based on the analysis.

The findings have vital scientific implications suggesting that the useful impact of a ketogenic weight loss program is perhaps enhanced by deliberate breaks.

“To place this in perspective, 13 million Individuals use a ketogenic weight loss program, and we’re saying that it’s good to take breaks from this weight loss program or there could possibly be long-term penalties,” stated David Gius.

Gius is lead creator of the brand new examine titled, “Ketogenic weight loss program induces p53-dependent mobile senescence in a number of organs,” revealed Might 17 within the journal Science Advances.

Different authors are also with the Division of Radiation Oncology and Mays Most cancers Heart, in addition to the Sam and Ann Barshop Institute for Longevity and Growing older Research, Heart for Precision Medication, College of Nursing, and Division of Nephrology within the Division of Medication at UT Well being San Antonio; and each the Houston Methodist Most cancers Heart and Houston Methodist Analysis Institute.

An excessive amount of of a great factor

A ketogenic weight loss program, popularly generally known as keto-friendly, is a high-fat, low-carbohydrate weight loss program that results in the technology of ketones, a sort of chemical that the liver produces when it breaks down fat. Whereas a ketogenic weight loss program improves sure well being circumstances and is common for weight reduction, pro-inflammatory results even have been reported.

The brand new examine exhibits that mice on two completely different ketogenic diets, and at completely different ages, induce mobile senescence in a number of organs, together with the center and kidney. Nonetheless, this mobile senescence was eradicated by a senolytic, or a category of small molecules that may destroy senescence cells, and prevented by administration of an intermittent ketogenic weight loss program routine.

“As mobile senescence has been implicated within the pathology of organ illness, our outcomes have essential scientific implications for understanding the usage of a ketogenic weight loss program,” Gius stated. “As with different nutrient interventions, it’s good to ‘take a keto break.'”