A low omega-6, omega-3 rich diet and fish oil may slow prostate cancer growth

A research led by UCLA Well being Jonsson Complete Most cancers Heart investigators affords new proof that dietary modifications might assist cut back most cancers cell progress in sufferers present process lively surveillance, a therapy method that includes common monitoring of the most cancers with out fast intervention.

The findings, printed within the Journal of Scientific Oncology, present {that a} weight loss plan low in omega-6 and excessive in omega-3 fatty acids, mixed with fish oil dietary supplements, considerably lowered the expansion price of prostate most cancers cells in males with early-stage illness.

“This is a crucial step towards understanding how weight loss plan can doubtlessly affect prostate most cancers outcomes,” mentioned Dr. William Aronson, Professor of Urology on the David Geffen Faculty of Medication at UCLA and first writer of the research.

“Many males are keen on way of life modifications, together with weight loss plan, to assist handle their most cancers and stop the development of their illness. Our findings recommend that one thing so simple as adjusting your weight loss plan might doubtlessly gradual most cancers progress and lengthen the time earlier than extra aggressive interventions are wanted.”

Many males with low-risk prostate most cancers select lively surveillance over fast therapy. Nonetheless, inside 5 years, about 50% of those males finally have to bear remedy with both surgical procedure or radiation. Due to this, sufferers are keen to seek out methods to delay the necessity for therapy, together with by means of dietary modifications or dietary supplements.

Particular dietary pointers on this space have but to be established. Whereas different medical trials have checked out rising vegetable consumption and nutritious diet patterns, none have discovered a big impression on slowing most cancers development.

To find out whether or not weight loss plan or dietary supplements can play a task in managing prostate most cancers, the UCLA-led crew performed a potential medical trial, referred to as CAPFISH-3, that included 100 males with low danger or favorable intermediate danger prostate most cancers who selected lively surveillance. Members have been randomly assigned to both proceed their regular weight loss plan or comply with a low omega-6, excessive omega-3 weight loss plan, supplemented with fish oil, for one 12 months.

Members within the intervention arm obtained dietary personalised counseling from a registered dietitian nutritionist, both in-person, by means of telehealth or by telephone. Sufferers have been guided on more healthy, decrease fats alternate options for top fats/excessive calorie meals (akin to utilizing olive oil or lemon and vinegar for salad dressing), and on lowering consumption of meals with greater omega-6 content material (akin to, chips, cookies, mayonnaise and different fried or processed meals).

The aim was to create a good stability of their consumption of omega-6 and omega-3 fat and make individuals really feel empowered to regulate how they alter their conduct. They have been additionally given fish oil capsules for additional omega-3s. The management group didn’t get any dietary counseling or take fish oil capsules.

The researchers tracked modifications in a biomarker referred to as the Ki-67 index, which signifies how briskly most cancers cells are multiplying—a key predictor of most cancers development, metastasis and survival.

Identical web site biopsies have been obtained initially of the research and once more after the one-year mark, utilizing a picture fusion gadget that helps observe and find the most cancers websites.

Outcomes confirmed that the low omega-6, omega-3 wealthy weight loss plan and fish oil group had a 15% lower within the Ki-67 index, whereas the management group noticed a 24% improve.

“This important distinction means that the dietary modifications might assist gradual most cancers progress, doubtlessly delaying and even stopping the necessity for extra aggressive remedies,” mentioned Aronson, who can also be the Chief of urologic oncology on the West Los Angeles Veterans Affairs Medical Heart and member of the UCLA Well being Jonsson Complete Most cancers Heart.

Whereas the outcomes are promising, researchers didn’t discover any variations in different most cancers progress markers, akin to Gleason grade, that are generally used to trace prostate most cancers development.

The investigators warning that additional analysis is important to substantiate the long-term advantages of omega-3 fatty acids and decreasing omega-6 in managing prostate most cancers. The findings assist additional, bigger trials to discover the long-term impression of dietary modifications on most cancers development, therapy outcomes and survival charges in males on lively surveillance.