Testosterone-Boosting Ingredient for Better Sexual Health by PLT Health Solutions

PLT Well being Options introduces TestFACTOR, a testosterone-boosting ingredient that includes Mangifera indica and Sphaeranthus indicus. Backed by scientific research, it enhances testosterone, vitality, and sexual well being in middle-aged males, with advantages like improved power, energy, and high quality of life.

TestFACTOR Part #1: Mangifera indica

Mangifera indica has been historically used not solely in Ayurvedic drugs but in addition in a number of different indigenous drugs methods to deal with numerous illnesses, together with diarrhea, dysentery, and rheumatism. It’s wealthy in potent bioactive constituents like mangiferin, a strong antioxidant with demonstrated antidiabetic, immunomodulatory, anti-genotoxic, and anti inflammatory properties.[5]

Apart from mangiferin, Mangifera bark additionally incorporates important compounds equivalent to catechins, quercetin, and gallic acid.[6] Current analysis has investigated these compounds for his or her potential in managing diabetes, immune operate, and oxidative stress.[7,8]

TestFACTOR Part #2: Sphaeranthus indicus

Sphaeranthus indicus, one other Ayurvedic famous person, has been used for tons of of years to deal with pores and skin ailments, fever, epilepsy, and gastrointestinal illnesses.[4,9] It incorporates bioactive constituents like sphaeranthanolide,[4,9] 7-Hydroxy frullanolide (7HF),[10] a sesquiterpene lactone to which the sphaeranthus in TestFACTOR is standardized, in addition to flavonoids and important oils. These constituents are recognized for his or her anti-inflammatory, antimicrobial, antioxidant, and liver-protective properties.[4,9,11]

Mixed, these two components demonstrated novel synergy throughout quite a few metabolic pathways, equivalent to rising mitochondrial biogenesis, upregulating the Mechanistic Goal of Rapamycin (mTOR), inducing muscle cell proliferation, inhibiting catabolic breakdown of muscle, and rising testosterone manufacturing. Throughout 4 scientific trials in males, this novel, patented ingredient mixture additionally elevated each free and whole testosterone, in addition to enhancing muscle energy and endurance:

2023 Research – Elevated Muscle Energy and Endurance

A randomized, double-blind, placebo managed scientific trial revealed in 2023 examined the energy and endurance enhancing results of TestFACTOR in 40 weight educated younger males. Contributors took both 650 mg TestFACTOR or a placebo for eight weeks whereas coaching 4 instances per week utilizing a typical “bro cut up” below skilled supervision.[12]

It’s vital to notice that these have been educated topics; every participant was required to have been lifting 3-4 hours per week, 4 instances per week, for six months.[12] This criterion is critical as a result of it’s typically a lot tougher for sports activities diet dietary supplements to point out results in educated topics than in untrained ones, lending further credibility to the examine’s findings.

Moreover, these topics have been wholesome. The imply age of the examine inhabitants was about 23, and the common BMI was 24,[12] indicating they have been match younger males at their organic peak. Their proximity to bodily genetic potential provides weight to any noticed results from TestFACTOR.

They have been additionally screened for doubtlessly confounding medical situations, equivalent to irregular liver panels or different critical infections, and instructed to keep away from all ergogenic aids whereas adhering to their regular diets.[12]

The TestFACTOR examine design.[12]

The examine members visited the lab on 5 separate events:

Screening go to
Randomization/baseline go to
Day 14
Day 28
Day 56

Energy assessments have been carried out on visits 2 by way of 5, whereas blood attracts have been taken on visits 1, 2, and 5.[12]

In case you aren’t aware of it, the “bro cut up” used on this examine has members divide their coaching right into a chest/shoulder day, a again day, a leg day, and an arm day. The lifting periods have been calibrated to every topic’s particular person 1RMs and adopted a three-step process:

Heat up with 2 units of 8-10 reps at 50% 1RM
Foremost session of 2-3 units of 10 at 70% 1RM, with 2 minutes of relaxation between units
Weight was incrementally added to the bar till it reached 90% 1RM

On go to days, members carried out solely the bodily evaluation workouts, which included bench press, leg press, cable pulldowns, handgrip energy, and a treadmill take a look at. The examine additionally tracked testosterone, cortisol, DHT, and creatine kinase, a metric for muscle harm.[12]

The TestFACTOR group (LI12542F6) dramatically outperformed the placebo group on all strength-related assessments.[12]

As proven within the inset chart, randomization on this examine was efficient, as bench 1RM, leg press 1RM, and handgrip energy have been roughly the identical between the teams at baseline.

However because the examine progressed, the TestFACTOR group (LI12542F6) completely creamed the placebo group.[12] Whereas each teams gained energy on all three assessments, the TestFACTOR group gained 500% extra energy than the placebo group on the bench press and leg press assessments.[12] The placebo group’s beneficial properties have been fairly stable (as anticipated), however the TestFACTOR beneficial properties have been extraordinary.

However much more spectacular than the raise enhancements was the grip energy enchancment. Anybody who’s educated onerous can inform you that grip energy is notoriously robust to enhance—you actually must struggle for even single-digit proportion beneficial properties. But extremely, the TestFACTOR group gained 30% extra handgrip energy than the placebo group throughout the 56-day examine interval.[12]

TestFACTOR’s capability to extend grip energy is undoubtedly a operate of its considerably androgenic impact.[12]

By simply the second week of the examine, the TestFACTOR group had considerably elevated their 1-rep max energy beneficial properties in bench press, leg press, and handgrip in comparison with the placebo group.[12]

From there, the TestFACTOR group’s benefits continued to develop, ensuing within the conclusion that by the top of the examine interval, the TestFACTOR group had gained 240% as a lot energy because the placebo group.[12]

The TestFACTOR group skilled important enhancements in androgen standing, undoubtedly the first issue of their energy beneficial properties.[12]

Train scientists have recognized for some time that testosterone standing influences grip energy greater than coaching does,[13] so if we see a lift in grip energy, we must also count on an enchancment in general androgen standing. And that’s precisely what the TestFACTOR examine discovered – when the researchers examined the themes’ androgen standing, they discovered that TestFACTOR elevated free testosterone by 17%, whereas lowering cortisol ranges by 22%.[12] Dihydrotestosterone (DHT) additionally elevated by 28% over baseline, however it didn’t obtain statistical significance towards placebo.[12]

The very best a part of this examine, in our opinion, is that each single noticed impact achieved statistical significance in comparison with placebo. Normally, after we cowl a examine like this, some results do and a few don’t – however as you’ll be able to see from the tables screenshotted under, each single noticed inter-group distinction achieved statistical significance (marked by a # superscript).[12]

TestFACTOR elevated endurance in addition to energy.[12]

When it got here to endurance, the examine measured it by two completely different strategies:

Variety of cable pull-down repetitions to failure at 80% 1RM
Time to exhaustion on a treadmill take a look at with a 2% improve in incline each 2 minutes

On each metrics, the TestFACTOR group outperformed the placebo group, gaining 96% extra endurance on the cable pull-downs and 107% extra endurance on the treadmill.[12]

TestFACTOR elevated bilateral bicep circumference and lean physique mass greater than placebo, whereas the TestFACTOR group additionally dropped extra fats than the placebo group.[12]

Since TestFACTOR improved energy, endurance, and androgen standing, it’s no shock there have been useful results on physique composition too. The TestFACTOR group skilled an roughly 3-4 instances better improve in bicep circumference, a robust indicator of muscle progress.[12]

One other wonderful end result was general lean physique mass – the TestFACTOR group gained a formidable 1.44 kg, whereas the placebo group gained barely any lean mass. Furthermore, the TestFACTOR group shed roughly 5 instances as a lot fats because the placebo group.[12]

No shock right here, since we already noticed how TestFACTOR elevated free testosterone, which considerably impacts muscle protein synthesis by way of its binding to the androgen receptor.[12]

2024 Followup Research

Then, in Could 2024, a second examine was revealed with a a lot bigger pattern dimension and located much more spectacular outcomes.

The examine concerned 99 males with a mean age of twenty-two — a reasonably large pattern, particularly by complement science requirements.[14] The massive dimension was to accommodate 4 separate arms within the examine.

It was a randomized, double-blind, placebo-controlled examine that assigned members to considered one of 4 situations:

Energetic 1 (A1) – 425 mg TestFACTOR WD (a water-dispersible type offering 325 mg of lively, half the dose used within the earlier examine)
Energetic 2 (A2) – 850 mg TestFACTOR WD (a water-dispersible type offering 650 mg of lively, the identical dose used within the earlier examine)
Placebo 1 (P1) – placebo
Placebo 2 (P2) – placebo however twice the units

All 4 teams underwent an similar resistance coaching (RET) program, the one distinction being that P2 accomplished twice the variety of units per session as the opposite teams. All members took their dietary supplements each morning throughout the examine interval.

At outlined intervals all through the 8-week examine, the analysis crew measured members’ energy on numerous lifts, in addition to sure biomarkers—together with the all-important androgen testosterone.[14]

In comparison with the placebo teams, the TestFACTOR teams skilled considerably better enhancements in 1-RM bench press, 1-RM leg extension, and whole muscle energy, with no important variations in physique weight.[14]

Along with most energy, the examine measured topics’ most reps on the identical lifts. As soon as once more, TestFACTOR was vastly superior to placebo – the TestFACTOR teams have been in a position to carry out about 10-15% extra reps than the placebo group![14]

Apparently, the impact appears to haven’t been strictly dose-dependent. Though the upper dose group achieved the very best beneficial properties, substantial and statistically important beneficial properties within the decrease dose group have been noticed as effectively, suggesting you can obtain the strength- and endurance-boosting results with a dose that simply matches into one capsule, or double up for max profit.

Be aware that the placebo teams additionally improved, as anticipated in topics who have been coaching – however TestFACTOR nonetheless beat them by a protracted shot.

Enhancements to androgen standing

TestFACTOR elevated each free and whole testosterone in direct proportion to its energy beneficial properties.[14]

As proven within the insert chart, TestFACTOR considerably elevated free and whole testosterone. Free T rose by 38% within the A2 group, whereas whole T elevated by 18%.[14]

Even the low-dose TestFACTOR group (A1) skilled a 30% increase in free T, which continues to be an enormous impact dimension!

Cortisol drop – simply as vital

And as soon as once more, TestFACTOR administration was related to a major drop in cortisol, which is arguably simply as huge of a deal because the T boosting impact, as a result of cortisol and testosterone have an antagonistic relationship on account of their opposing roles within the physique. Whereas testosterone is, as everyone knows, an anabolic hormone that helps muscle progress, protein synthesis, and tissue restore, cortisol is a catabolic hormone that gives power by breaking down protein and muscle tissue.[15] No shock, then, that elevated cortisol ranges can inhibit testosterone manufacturing by suppressing the hypothalamic-pituitary-gonadal (HPG) axis and decreasing luteinizing hormone (LH) secretion,[16] that are each important for testosterone synthesis.

What makes this tremendous spectacular, and vital, is that TestFACTOR decreased cortisol ranges throughout a heavy resistance coaching cycle, which is when cortisol rises probably the most (because it did in each placebo teams), and likewise a interval after we can profit much more than typical from maintaining it below management. In spite of everything, the purpose of resistance coaching is to construct energy and muscle, and cortisol straight interferes with the accomplishment of each objectives.

What Do These Research Imply For Older Males? What do they imply for ladies?

On condition that the primary examine was performed in males aged 18 to 40, and the second in males 19 to 29, males who’ve aged out of those brackets might surprise how these outcomes apply to them. And ladies would possibly surprise the identical.

The reply is that, usually, it’s a lot tougher to naturally improve testosterone manufacturing in youthful males in comparison with older males, since younger males are sometimes nearer to their genetic potential. Subsequently, any complement that successfully boosts testosterone on this inhabitants is sort of definitely going to work even higher in an older inhabitants. Girls, then again, need to expertise the energy advantages with out rising their testosterone.

2024 Poster Presentation Research: TestFACTOR Complement Enhances Energy and Mobility in Older Adults, and Testosterone in Older Males

An summary and poster presentation of a examine have been not too long ago revealed in 2024 exhibiting that TestFactor is efficacious in an older inhabitants.[17,18]

The randomized, double-blind, placebo-controlled examine was performed over 12 weeks with 92 adults aged 55-70 (46 males and 46 ladies) divided into two teams: one performing calisthenic workouts alone (thrice per week) and the opposite performing the identical workouts with day by day TestFACTOR supplementation (650 mg/day).

Energy, endurance, mobility, physique composition, and testosterone ranges have been tracked all through the examine at baseline, week 4, week 8, and week 12. Energy was assessed by way of leg extensions and handgrip assessments, endurance measured by leg extension repetitions to failure, and useful mobility evaluated utilizing a six-minute stroll and sit-to-stand assessments.

Key Findings / Highlights

Though each teams confirmed important enhancements in energy, endurance, and mobility by week 12, the TestFACTOR group demonstrated considerably better beneficial properties in leg energy, grip energy, strolling distance, and sit-to-stand efficiency in comparison with the placebo group.[17,18]

The short breakdown is nothing in need of staggering:

4.2x better enchancment in leg energy versus train alone
4.5x better enchancment in grip energy versus train alone
52% better resistance to muscular fatigue versus train alone
86% better enchancment in useful mobility versus train alone
86% enchancment in strolling velocity versus train alone
2.1x extra perceived power and vitality

Let’s take a better take a look at the information:

Energy Enhancements

TestFACTOR Considerably ImprovedTotal and Free Testosterone

Leg Extension (LE-1RM): Important beneficial properties in leg extension energy have been noticed in each teams, however TestFACTOR members demonstrated better enhancements at each time level (weeks 4, 8, and 12). These results had a robust interplay between group and time (p<0.001), exhibiting that the complement considerably accelerated beneficial properties over time in comparison with train alone​.[17,18]
Grip Energy: In contrast to the exercise-only group, TestFACTOR supported enhanced grip energy in members constantly throughout all measured intervals (weeks 4, 8, and 12). A foremost impact of time, remedy, and a group-time interplay (p<0.001) additional emphasised TestFACTOR’s function in bettering grip energy, a profit not achieved by calisthenics alone​.[17,18]

Endurance Beneficial properties

Leg Extension Repetitions to Failure (LE-RTF): Each teams confirmed endurance enhancements, however the TestFACTOR group exceeded the placebo group from week 4 onward (p=0.007 for group impact). This means TestFACTOR’s extra assist in muscular endurance early on, indicating a cumulative profit all through the examine​.[17,18]

Useful Mobility

6-Minute Stroll Take a look at (6MWT): Strolling distance improved in each teams, however TestFACTOR supplementation led to considerably better beneficial properties in strolling distance by week 12 (p=0.008 for group x time interplay). This impact implies enhanced stamina and cardiovascular profit within the supplemented group.[17,18]
Sit-to-Stand Take a look at (STS): Enhancements have been seen throughout each teams, however these utilizing TestFACTOR had extra important will increase in repetitions by week 12, although the interplay impact approached significance (p=0.064). This endpoint helps TestFACTOR’s impression on useful energy and mobility when mixed with a fundamental train routine​.[17,18]

Physique Composition

Lean Physique Mass (LBM): TestFACTOR members skilled important will increase in lean physique mass from baseline, not like the exercise-only group. The complement group confirmed notable variations (p<0.05) in lean mass, particularly important in each female and male members by week 12​.[17,18]
Complete Physique Fats (TBF): TBF declined solely within the TestFACTOR group, the place reductions have been statistically important in comparison with the placebo (p<0.05). This will point out TestFACTOR’s function in enhancing metabolic operate alongside muscle variations​.[17,18]

Hormonal Affect

Testosterone Ranges: In male members, TestFACTOR considerably elevated testosterone ranges over baseline, whereas train alone confirmed a smaller improve (p<0.01 for group impact in males). Girls didn’t exhibit modifications in testosterone in both group​.[17,18]

TestFACTOR Poster Presentation Research Conclusions

General, this examine emphasizes TestFACTOR’s potential for enhancing a number of features of bodily well being in older adults when mixed with minimal train. Key advantages have been noticed in muscle energy, endurance, useful mobility, and physique composition, significantly lean physique mass retention and testosterone ranges in males.

The improved and accelerated beneficial properties within the TestFACTOR group underline the complement’s efficacy, particularly in endpoints like leg energy, grip energy, and strolling distance, showcasing it as a supportive addition for older adults aiming to enhance bodily resilience and metabolic well being.

The poster presentation for the 12-week intervention confirmed quite a few statistically important (and clinically important) advantages when it comes to energy, endurance, mobility, and hormone standing.[18]

Male Sexual Well being and Vitality Research On The Method: Phenomenal Preview Knowledge

Researchers have accomplished a examine that’s nonetheless unpublished at time of press (October 2024), however PLT Well being has teased some phenomenal outcomes at SupplySide West:

This examine was an 8-week randomized, double-blind, placebo-controlled trial involving 60 wholesome males aged 40-65 (imply age 51). Contributors have been recreationally lively, with a traditional to chubby BMI. The examine in contrast outcomes for members taking a day by day 325 mg dose of TestFACTOR versus placebo. The first endpoint was change in serum Complete testosterone. Different key metrics included modifications in sexual operate, different hormone ranges, psychological and bodily power, grip energy, sleep, and perceived stress taken at baseline, 1, 2, 4, and eight weeks.

Key Findings

Hormone Ranges

Complete Testosterone: Complete testosterone elevated considerably within the TestFACTOR group, exhibiting a 19% enchancment over baseline by week 8. Statistically important beneficial properties versus placebo started at week 2 (p<0.05), indicating a speedy onset of motion for TestFACTOR in supporting testosterone ranges.
Free Testosterone: Free testosterone ranges rose by 20% from baseline inside the TestFACTOR group, once more reaching significance as early as week 2 when in comparison with the placebo group​.

Sexual Perform

TestFACTOR Considerably Improved SexualFunction Throughout Quite a few Domains

General Sexual Perform: TestFACTOR improved sexual operate by 48%, as measured by the Adjustments in Sexual Perform Questionnaire (CSFQ). This enchancment grew to become statistically important at week 2 and spanned all measured domains: pleasure, frequency, want, arousal, and orgasm.
Particular person Domains:

Pleasure/Satisfaction: Elevated by 44%.
Frequency: Improved by 58%, suggesting a extra constant optimistic impression on sexual exercise.
Curiosity/Need: Enhanced by 45%.
Arousal/Erection High quality: Improved by 49%.
Orgasm/Ejaculation: Notably elevated by 46%. These domain-specific beneficial properties reinforce TestFACTOR’s supportive function in a number of features of sexual well being and general wellness.

Vitality and Fatigue

Chalder Fatigue Scale: Complete fatigue scores decreased by 57% within the TestFACTOR group by week 4, in comparison with minimal change within the placebo group. This was accompanied by a 50% enchancment in bodily power and a 67% enchancment in psychological power by the top of the 8-week examine.
These fatigue reductions spotlight TestFACTOR’s potential to boost each bodily and psychological power in a comparatively quick interval.

Bodily Energy and Longevity

Grip Energy: TestFACTOR yielded a 14.5% enchancment in grip energy, thought-about a clinically significant improve. This profit was important from week 4 onward, with a 5.5 kg acquire by week 8. Improved grip energy has been related to lowered dangers of cardiovascular occasions, mortality, and general longevity, suggesting broader well being implications.

High quality of Life (QoL)

Stress and Sleep High quality: Contributors reported a marked discount in perceived stress and enhancements in sleep as early as week 4. These outcomes, measured by the Perceived Stress Scale (PSS) and the Athens Insomnia Scale (AIS), mirror TestFACTOR’s potential to assist psychological wellness and restoration.
Vitality: The SF-36 vitality subscale confirmed substantial enchancment by week 8, supporting basic high quality of life enhancements in TestFACTOR customers​.

Research Conclusion: We Can’t Wait to See this Printed!

This 8-week examine underscores TestFACTOR’s multi-dimensional advantages in middle-aged males, spanning hormone assist, enhanced power and energy, improved sexual well being, and lowered fatigue. Notable findings embody the complement’s early efficacy in boosting testosterone and grip energy, that are essential indicators of long-term vitality. With important enhancements in sexual operate and different high quality of life metrics, TestFACTOR emerges as a promising complement for supporting hormonal and useful well being in ageing adults.

The total publication of this examine is coming quickly, so keep tuned to the PricePlow Weblog — we’ll cowl this and replace this text as soon as it’s revealed.