The Future of Brain Health: Cognizin Citicoline GENE Research by Danielle Citrolo

In Episode 153 of the PricePlow Podcast, we’re joined by Danielle Citrolo, Vice President of Scientific and Regulatory Affairs at Kyowa Hakko USA, to debate thrilling new analysis on Cognizin Citicoline.

Danielle Citrolo of Kyowa Hakko USA - Cognizin Citicoline Gene Research

Danielle Citrolo of Kyowa Hakko USA joins PricePlow Podcast Episode #153 and discusses groundbreaking new gene analysis on Cognizin Citicoline and its potential for supporting mind well being and cognitive perform.

Cognizin, an industry-leading nootropic ingredient identified for its advantages in mind well being, has lengthy been praised for its capability to assist focus, reminiscence, and a focus. On this episode, Danielle dives deep into the most recent findings, highlighting the cutting-edge science behind how Cognizin impacts gene expression on the mobile degree, providing contemporary insights into the way it helps cognitive perform.

Analyzing Cognizin Citicoline on the Genetic Degree

Danielle explains how latest research utilizing a complicated triculture mannequin of mind cells revealed new mechanisms of motion for citicoline. By inspecting gene expression and neuronal exercise, researchers have been in a position to uncover how Cognizin impacts mind construction and performance, from enhancing neuronal communication to selling wholesome ldl cholesterol synthesis within the mind. These discoveries take the understanding of Cognizin’s advantages to the subsequent degree, providing a deeper take a look at how this highly effective nootropic works past simply boosting focus and a focus.

All through the episode, Danielle additionally touches on the broader implications of this analysis, notably within the areas of mitochondrial well being and neuroprotection. With ongoing research into its potential advantages for girls’s cognitive well being, sleep high quality, and temper regulation, Cognizin continues to prepared the ground within the nootropic {industry}. Whether or not you’re a biohacker, a well being fanatic, or just curious in regards to the newest developments in mind well being, this episode is full of thrilling discoveries.

Hearken to the dialogue on the podcast app of selection, however this one’s in all probability finest to look at on YouTube within the video embedded under, since Danielle shares a presentation with us:

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Video: Daneille Citrolo of Kyowa Hakko Talks Cognizin Gene Analysis

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00:00 – Introduction to Danielle

On Episode #153 of the PricePlow, our visitor is Danielle Citrolo, Vice President of Scientific and Regulatory Affairs at Kyowa Hakko USA, producers of Cognizin Citicoline. She introduces herself and offers an outline of Cognizin, highlighting its advantages for focus, consideration, reminiscence, and general mind assist.

Cognizin® Citicoline is dubbed the The Mind Choline not simply because it offers choline, however as a result of it additionally provides cytidine, which can also be wanted for the synthesis of phosphatidylcholine

Danielle emphasizes that Cognizin stands out within the nootropic market on account of its capability to assist mind construction and performance whereas providing instant cognitive advantages. Mike and Ben recall an early expertise with the ingredient in 2013, praising its “experiential” influence. She additionally mentions ongoing analysis into Cognizin, with extra scientific research in progress to additional discover its advantages.

02:15 – Exploring the New Examine on Cognizin

Danielle discusses the most recent research on Cognizin Citicoline, specializing in the way it impacts gene expression. She explains that the analysis examines how citicoline impacts mRNA, which in flip regulates proteins, enzymes, and metabolic pathways, revealing the physique’s mobile response.

This cutting-edge analysis, utilizing a triculture mannequin to simulate mind tissue, sheds mild on the precise mechanisms behind Cognizin’s advantages, reminiscent of improved focus, consideration, and mind well being. Whereas earlier research confirmed cognitive advantages, this new research delves into the genetic and neuronal community degree, offering deeper perception into how the complement works.

07:15 – Understanding Metabolomics and Cognizin

See PricePlow’s ISSN 2024 Convention Recap, Powered by Cognizin® Citicoline

Danielle delves into the rationale behind conducting metabolomics analysis on Cognizin Citicoline. She explains that earlier research have proven how citicoline enhances phospholipids for mind cell well being, will increase acetylcholine and dopamine for focus and a focus, and improves mitochondrial perform by boosting ATP ranges within the mind. The brand new research goals to grasp the underlying mechanisms at a mobile degree utilizing transcriptomics, which measures mRNA expression to disclose how DNA is translated into organic motion.

To realize this, researchers used pluripotent stem cells differentiated into three forms of mind cells—neurons, microglia, and astrocytes—to simulate mind tissue. The research measured neuronal excitatory exercise and used mRNA sequencing to look at the results of citicoline. Danielle additionally explains the importance of the three cell sorts in mind perform and neuroprotection, offering deeper perception into how Cognizin helps mind well being.

12:15 – The Triculture Mannequin Defined

Danielle explains the two-part research utilizing triculture cells to simulate mind tissue and discover the results of citicoline (Cognizin). The primary half concerned electrophysiology testing to measure how citicoline, together with choline and citidine, excites neurons in comparison with a placebo. Outcomes confirmed that citicoline and choline considerably outperformed the placebo in neuron pleasure and community exercise.

How Cognizin Citicoline Works

The second half concerned mRNA sequencing to determine how gene expression was altered by citicoline, choline, and citidine, in comparison with a optimistic management (donepezil) and a saline answer. This evaluation helped pinpoint the molecular pathways and potential well being advantages of citicoline. Danielle highlights the significance of this analysis in uncovering new mechanisms behind citicoline’s cognitive advantages and mentions a collaboration with Thorne HealthTech for this research.

18:00 – Gene Expression and Cognizin’s Influence

Danielle discusses superior findings from the research on Cognizin by analyzing gene expression via “volcano plots.” She explains that citicoline considerably impacted 749 genes, differentiating it from placebo, with lots of the upregulated genes linked to mind perform and construction, notably throughout the central nervous system (CNS). She highlights a selected gene, NCS1, concerned in reminiscence and studying, which was downregulated by citicoline, equally to the drug donepezil, generally utilized in Alzheimer’s sufferers. Nevertheless, NCS1 is usually upregulated in ailments like schizophrenia and bipolar dysfunction, although its scientific relevance stays unclear.

Citicoline (Cognizin) vs Alpha-GPC and Standard Choline

Solely citicoline (Cognizin) is ready to promote each acetylcholine and the three mind cell membranes, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine!

She emphasizes that whereas the research offers insights into how citicoline helps mind well being, additional evaluation is required to find out the sensible implications of those findings. She notes that this analysis, introduced at a prestigious convention, represents cutting-edge metabolomics, going past typical research to grasp not simply if however how citicoline works on the mobile degree.

23:45 – Future Analysis Instructions and Purposes

Danielle discusses the molecular pathways upregulated and downregulated by citicoline (Cognizin) and their implications for mind well being. Citicoline enhances ldl cholesterol synthesis, neuron communication (synapses), and neuronal improvement, all essential for sustaining mind perform. She explains that clearing extra ldl cholesterol from the mind, which may construct up as neurons die, is important for stopping neurotoxicity and selling blood stream. Moreover, citicoline downregulates alpha-beta secretion, which is linked to amyloid plaques related to Alzheimer’s illness.

Though the precise position of those plaques is debated, decreasing alpha-beta secretion is seen as a optimistic final result. The research additionally highlights the affect of citicoline on mitochondrial perform, probably enhancing the manufacturing of ATP (the cell’s power forex).

28:15 – Potential in Girls’s Well being and Cognitive Operate

Cognizin Citicoline Paired Associates Scores

Enchancment to Paired Associates scores between the citicoline and placebo teams.[1]

Danielle explores the potential advantages of Cognizin on mitochondrial well being and its relevance to mind perform and girls’s well being. She notes that mitochondria play a vital position in varied dysfunctions, notably in mind well being, and there may be rising curiosity in understanding how citicoline can assist mitochondrial perform. The dialog touches on the necessity for additional analysis to grasp citicoline’s influence on ldl cholesterol metabolism, neuron well being, and its capability to stop neuronal dying, which is important as we age. Citrolo additionally discusses preliminary findings indicating that citicoline might assist scale back neurotoxic amyloid plaques and affect genetic pathways associated to mitochondria.

She mentions ongoing research into how hormonal adjustments, particularly throughout menopause, may have an effect on mind perform and the way citicoline may mitigate these results. Moreover, a research in middle-aged ladies confirmed optimistic outcomes for focus and a focus, with individuals reporting a want to proceed utilizing the complement. Citrolo hints at future analysis exploring citicoline’s broader potential in ladies’s well being and sleep high quality.

36:30 – Conclusion and Future Research

Danielle discusses the stimulating nature of Cognizin and its potential influence on sleep, noting that whereas it’s not a sedative, it might enhance sleep high quality with out inflicting drowsiness. The hosts additionally speculate on Cognizin’s position in vivid dreaming, as excessive doses of choline have been linked to lucid dreaming experiences.

She shares insights into ongoing analysis at Kyowa USA, together with a motor pace research and a temper research to discover acute results on temper. She highlights their dedication to patenting advantages based mostly on human analysis to distinguish themselves within the market. The dialog ends with the staff expressing pleasure in regards to the future course of Cognizin’s analysis and its increasing purposes.